Ossification endochondrale
The ossification endochondrale is a primary mechanism of ossification, like the endoconjonctive Ossification.
The mésenchymateuses cells of the Périoste are transformed into Ostéoblaste S. They then will synthesize osseous matrix to transform itself into Ostéocyte S. the osseous matrix will induce the transformation more and more C. mésenchymateuses into osteoblasts.
The osteoblasts communicate between them by nexus. Starting from a signal, they secrete a matrix to be immured: osteoblastic affixing.
At the same time, 2nd process:
The chondrocytes hypertrophy and synthesize alkaline phosphatase (PA) which will be calcified. Then penetration of a conjonctivo-vascular bud in the center of the cartilage from where apoptose of the Chondrocyte S hypertrophied. This bud induces the elimination of the chondrocytes dead neighbors and digs the 1st medullary cavity. Then primary ossification follows the cartilagineuses spans.
Fibroblast S - > Osteoblast S - > osteoblastic affixing - > primary education bone
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