Muscular hypertrophy in connection with a disorder of the myostatine

The muscular hypertrophy in connection with a disorder of the myostatine is a muscular disorder by change of the Gène GDF8 localized on the Chromosome 2.

This change appears by an increase in the muscular size but not being accompanied always by an increase in the muscular force. The greasy fabric in connection with the muscle reached is often weak épaisseur.
The carriers Homozygote S or hétèrozygote S present the same clinical signs which depend only on the quantity of myostatine présente.
The homozygotes have muscles twice bulkier than the normal. There does not exist cardiac attack and not intellectual repercussion of this change. Myoclonie S can appear after stimulation.

Sources

  • Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MANDELEVIUM. MIM Number: 601788 * Kathryn R Wagner, Nicole Johnson, Myostatin-Related Hypertrophy Muscle In: GeneReviews At GeneTests: Medical Genetics Information Resource (database online). Copyright, University off Washington, Seattle. 1997-2005.

Associations

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